I tow a 34ft Sandpiper tag toyhauler. The thing is huge but I have never had any problems towing it. The only draw back I can think of is turning around with it. With a 5th wheel you have a tighter turning radius, but then again when do you ever really have to make u-turns with a toyhauler? The only time I have to do a few point turn with mine is when I dump my tanks at my buddy's back yard. (that sounds funny ) I have never had a problem with it even in RV parks or parking lots.
The extra bed space is nice for firewood, extra bikes, gas cans, etc.
You won't have to buy an expensive hitch either. here's my .02.